Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)
نویسندگان
چکیده
منابع مشابه
Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)
Immunoglobulins such as IgG and IgM have been shown to induce anti-tumour cytotoxic activity. In the present study we therefore explore total serum IgG and IgM expression dynamics in 23 known-aged Tasmanian devils (Sarcophilus harrisii) of which 9 where affected by Devil Facial Tumour Disease (DFTD). DFTD is clonally transmissible cancer that has caused massive declines in devil numbers. Our an...
متن کاملCathelicidins in the Tasmanian devil (Sarcophilus harrisii)
Tasmanian devil joeys, like other marsupials, are born at a very early stage of development, prior to the development of their adaptive immune system, yet survive in a pathogen-laden pouch and burrow. Antimicrobial peptides, called cathelicidins, which provide innate immune protection during early life, are expressed in the pouch lining, skin and milk of devil dams. These peptides are active ag...
متن کاملThe pathology of devil facial tumor disease (DFTD) in Tasmanian Devils (Sarcophilus harrisii).
A disfiguring and debilitating neoplastic condition known as devil facial tumor disease (DFTD) has been discovered in wild Tasmanian Devils (Sarcophilus harrisii) across 51% of its natural range, with population declines of up to 80% in some areas (C. Hawkins, personal communication). Between 2001 and 2004, 91 cases were examined. The tumors presented as large, solid, soft tissue masses usually...
متن کاملRelict or reintroduction? Genetic population assignment of three Tasmanian devils (Sarcophilus harrisii) recovered on mainland Australia
Today, the Tasmanian devil (Sarcophilus harrisii) is found only on the island of Tasmania, despite once being widespread across mainland Australia. While the devil is thought to have become extinct on the mainland approximately 3000 years ago, three specimens were collected in Victoria (south-eastern Australia) between 1912 and 1991, raising the possibility that a relict mainland population sur...
متن کاملGenetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil).
The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction because of a contagious cancer known as Devil Facial Tumor Disease. The inability to mount an immune response and to reject these tumors might be caused by a lack of genetic diversity within a dwindling population. Here we report a whole-genome analysis of two animals originating from extreme northwest and southeast Tasman...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep25093